Journal: Current biology : CB

Article Title: Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits

doi: 10.1016/j.cub.2021.10.009

Figure Lengend Snippet: Influence of drug condition (A, B; monkeys) and genotype (C, D; mice) on LFP power (A, C) and pairwise phase consistency (PPC) between spikes and LFPs (B, D). LFP signals were convolved with a set of complex Morlet wavelets in the frequency range of 1–100 Hz using the Matlab FieldTrip114 toolbox. After assigning phase angles to each spike (relative to LFP oscillations at a given frequency), PPC is defined as the mean cosine between the phase angles of all possible pairs of spikes, capturing the tendency for spikes to occur at consistent phases of LFP oscillations64. (A, C) Mean LFP power spectra in monkeys (A) and mice (C). LFP power was significantly reduced by blocking NMDAR in monkeys and hemizygous deletion of Dgcr8 in mice (black dots above horizontal axis indicate p < 0.05 between conditions by t-test at each frequency, FDR corrected for the number of tests using the Benjamini-Hochberg method). Error bars indicate SEM over LFP channels (electrodes). The dip at 60 Hz in the monkey power spectra reflects notch filtering. (B, D) Median PPC as a function of frequency in monkeys (B) and mice (D). PPC was significantly reduced by blocking NMDAR in monkeys (NSaline = 960 neurons, NDrug= 763 neurons) and hemizygous deletion of Dgcr8 in mice (NWT = 79 neurons, NDgcr8 = 128 neurons) (black dots above horizontal axis indicate p < 0.05 between conditions by Wilcoxon Rank Sum test at each frequency, FDR corrected for the number of tests using the Benjamini-Hochberg method).

Article Snippet: LFP signals were convolved with a set of complex Morlet wavelets in the frequency range of 1–100 Hz using the Matlab FieldTrip 114 toolbox.

Techniques: Blocking Assay